Computer model locks in 49ers vs. Cardinals picks, score prediction, SGP for NFL Week 11

Arizona Cardinals vs San Francisco 49ers is one of Week 11’s late-afternoon NFL games. The 49ers have a record of 6-4, and they are coming off their loss to the Los Angeles Rams. Meanwhile, the Cardinals have a record of 3-6. San Francisco won the match-up in Week 3 with a score of 16-15. Kickoff at State Farm Stadium will be 4:25. ET on FOX. According to the most recent 49ers vs. Cardinals betting odds, the 49ers are 3-point favorite. The total number of points scored for the 49ers vs. Cardinals game is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.Click here to bet 49ers vs. Cardinals at BetMGM Sportsbook, where new users get either $150 in bonus bets if your first bet wins or up to $1,500 in bonus bets if your first bet loses:Where to bet on 49ers vs. CardinalsWhere to watch 49ers vs. Cardinals on SundayWhen: Sunday, Nov. 16Time: 4:25 p.m. ETTV: FOXFollow along: CBS Sports App49ers vs. Cardinals betting previewOdds: 49ers -3, over/under 48.5This was a low-scoring affair back in Week 3, with just 31 points scored. Both teams have played more Over than Under this season. Six of San Francisco’s 10 games went Over and five of Arizona’s nine. The 49ers are 5-5 against the spread, while the Cardinals are 5-4 ATS.Click here to bet 49ers vs. Cardinals at FanDuel Sportsbook, where new users get $150 in bonus bets if their first bet of at least $5 wins:49ers vs. Cardinals SGPUnder 48.5 (-112, DraftKings)49ers -3 (-108, DraftKings)49ers first to score (-135, DraftKings)Final odds: +535 at DraftKings (wager $100 to win $535)Model’s 49ers vs. Cardinals score prediction, picksThe model has the 49ers winning this Week 1 rematch in the majority of simulations, but it does see value in backing the Cardinals on the money line at plus odds as Arizona wins outright in 44% of simulations. The model leans to the Under here, as that hits in nearly 60% of simulations, and this was a very low-scoring game back in Week 3 when both teams were healthier than they are now.49ers vs. Cardinals score prediction: 49ers 25, Cardinals 22 Want more Week 11 NFL picks?You’ve seen the model’s best bets for San Francisco 49ers vs. Arizona Cardinals. Now, get against the spread, total and money-line picks for every Week 11 NFL game here, all from the model that’s simulated every game 10,000 times. 

2025-11-15 22:02:10