Tom Aspinall will defend the UFC Heavyweight Championship on Saturday, when he takes on Ciryl Gane. Ciryl Gane, the number one contender, will be fighting at UFC 321 Aspinall Vs. Gane. Aspinall was first awarded the interim UFC heavyweight title in November 2023 with a KO of Sergei Pavlovich. In July 2024, he defended it with a KO of Curtis Blaydes. On June 21st, 2025 he became the undisputed champion. Gane has just won a split-decision victory over Alexander Volkov last December at UFC 310. Aspinall, the favorite (risking $380 for $100) is at odds of -380 while Gane has odds of +300. Mackenzie Dern will be the -165 favourite against Virna Jandiroba (+140). This is a women’s strawweight title bout. Before locking in any UFC 321: Aspinall vs. Gane picks, make sure you see the MMA predictions and betting advice from SportsLine expert Daniel Vithlani.New users can target the DraftKings promo code, which offers $300 in bonus bets if your bet wins + 3 months of NBA League Pass:Vithlani is a highly-analytical UFC bettor who has been a consistent winner for SportsLine members since making his debut in January 2023 with a 5-0 record for UFC 283. In fact, he’s up over $1,500 on his UFC main-card sports betting picks.His other highlights include calling an upset for Sean O’Malley (+210) against Aljamain Sterling (-250) at UFC 292 as part of a 4-1 main card and his UFC 299 winners included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130). Anyone who has followed him at sportsbooks and on betting apps could be way up.Now, Vithlani has studied Tom Aspinall vs. Ciryl Gane from every angle and revealed his top betting picks and best bets. To see them, head to SportsLine. New users can also target the latest Underdog promo code, good for $100 in site credits when you play $5 with the promo code CBSSPORTS2 in select states.Aspinall vs. Gane preview Aspinall, 32, has been on a roll. He has won 11 out of 12 fights. This includes a win against Blaydes who defeated Aspinall during UFC Fight Night Blaydes vs. Aspinall, in July 2022. In December 2014 he became a professional fighter in Manchester, England. His UFC debut was in July 2020. He is 15-3 in his career with 12 knockouts and three submissions. Aspinall has been awarded Performance of the Night seven times. This is tied for the most in UFC’s history. In UFC’s history, he has the shortest fight average at 2 minutes and two seconds. He also has the most knockdowns per fifteen minutes with 4.09 at the second place. In 2020, he placed ninth in the UFC Newcomer-of-the Year category. In 2022, he was ranked No. 3 for UFC Submission of the year. In 2024, he earned two MMA awards – Breakthrough Fighter of the Year and Comeback of the Year. SportsLine has his analysis and picks. Gane, 35, a fighter from Paris, France, started his professional fighting career in August 2018. In his first three fights, Gane won by knockout. This caught the attention of UFC. In August 2019, he made his promotional debut, winning a submission victory over Raphael Pessoa in UFC Fight Night Shevchenko Vs. Carmouche 2 at UFC Fight Night. He won his first ten matches of his professional career. This included a knockout of Derrick Lewis during the third round, which earned him the interim UFC Heavyweight Championship and Performance of the Night in August 2021. Six of his victories were by knockout. Three by submission, and four by decision. In 2019, he was ranked No. 2 in the UFC Newcomer of The Year rankings and No. 3 in the UFC Fighter of the year rankings. In 2021, he was the third Fighter of the year. In 2022, his knockout of Tai Tuivasa in the third round at UFC Fight Night: Gane Vs. Tuivasa earned him the seventh-ranked Fight of the year. Only SportsLine has his analysis and picks. UFC 321 Aspinall-Gane predictionsWe reveal Brasco’s UFC 321 Aspinall-Gane prediction: Jose Delgado to defeat Nathaniel Wood in a preliminary featherweight matchup.Vithlani stated that Delgado was a rising featherweight who looked legit. Delgado, who trains out of the MMA Lab gym in Los Angeles, is a rangy striker with explosive knees and elbows. Delgado’s last fight saw him knock out a tough fighter in less than 30 seconds. Delgado stands 5 feet 11 inches tall and has a 73 inch reach. This gives him a size advantage. Wood, a tactical kickboxer who has UFC experience will be a good challenge for Delgado. Wood will not be able outpoint Delgado in three rounds. Delgado has a 10-1 professional career and is a more aggressive and dangerous fighter. Delgado’s size and his pressure will help him win this fight.” You can make this pick at FanDuel, where new users can also check out the latest FanDuel promo code and get $300 in bonus bets instantly at FanDuel if your $5 bet wins. UFC 321 Aspinall-Gane main fight cards, oddsVithlani is confident about Aspinall-Gane and the other matches on the UFC 321 Aspinall-Gane card. He is also backing a wrestler who will “use physicality to win a big fight.” Who wins UFC 321, Aspinall vs. Gane and how does the fight finish? Visit SportsLine now to get detailed picks and analysis from the incomparable expert who is up over $1,500 on his UFC main-card picks, and find out.UFC 321: Aspinall vs. Gane main fight card, odds See picks at SportsLine.The odds are subject to change. Tom Aspinall (+380) vs. Ciryl Ganes (+300)Virna Jandiroba (+140), vs. Mackenzie Dern (+165)Umar Nurmagomedov (+550) vs. Mario Bautista +410)Alexander Volkov (+190) vs. Jailton Almeida(-230)Aleksandar Rakic (+1100) vs. Azamat Mu
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