The NFL Week 17 schedule rolls on with two more games on Saturday 10 on Sunday and then the standard ‘Monday Night Football’ slot. Several of the remaining games have a direct bearing on the NFL playoffs and seeding. In the NFC, the NFC West-leading Seattle Seahawks take on the NFC South-leading Carolina Panthers. Seattle enters as a 7-point favorite at DraftKings Sportsbook. In the AFC South, the division-leading Jacksonville Jaguars take on the Indianapolis Colts. The Jaguars are favored by 5.5 points. Sunday’s largest spread is Patriots (-13.5) vs. Jets, while another larger spread is on ‘Monday Night Football,’ with the Rams (-7.5) vs. Falcons. The smallest spreads Sunday include Giants vs. Raiders (+2.5), Saints (-2.5) vs. Titans, Eagles vs. Bills (-1.5) and Bears vs. 49ers (-3) on ‘Sunday Night Football.’ Seattle entered the weekend as the NFC’s top seed, while Denver remains first in the AFC after its Christmas win over the Chiefs. Before making any Week 17 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season. For Week 17 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 16 games. You can only see the AI predictions for the Week 17 NFL schedule here.Top Week 17 NFL AI picksAfter analyzing every game in Week 17, the AI says the Steelers (-3, 34), who have won three in a row, cover comfortably against the Browns.
The Steelers have gone over in two of their last three games, while the over has hit in six of the past 10 Browns games. Bet the Over 34.5 in the latest DraftKings promo code, which offers $200 in bonus bets if your first bet wins:
Pittsburgh is looking to win its…
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2025-12-27 16:09:28

