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    NFL Divisional Round betting preview: Bills-Broncos, 49ers-Seahawks on Saturday

    We’re down to just eight teams in the NFL playoffs, and only four will remain after this weekend concludes. The action kicks off with two contests on Saturday, with both of the No. 1 seeds in the NFL in action. The Denver Broncos host the Buffalo Bills at 4:30 p.m. ET in the first game of the Divisional Round, while the Seattle Seahawks face the San Francisco 49ers for the third time this season in the prime time slot Saturday night at 8 p.m. ET. Here, we break down everything bettors need to know for these two matchups, including NFL betting lines and odds courtesy of DraftKings Sportsbook.Bills vs. Broncos (4:30 p.m. ET)
    The Bills survived a close 27-24 matchup in Jacksonville to advance to the Divisional Round and a date with the No. 1 seed Broncos. Buffalo needed and got a big game from Josh Allen, who had 306 yards of offense and three total touchdowns against a Jaguars team that ranked No. 1 against the run this year. Allen and Co. face as much pressure as a No. 6 seed can face given there’s no Patrick Mahomes, Lamar Jackson or Joe Burrow in the AFC playoff field this year. Buffalo went 3-3 against playoff teams in the regular season before taking down the Jags in Jacksonville on Sunday.The Broncos took advantage of a down year from Mahomes and the Chiefs to go 14-3 and win the division and secure home-field advantage in the postseason. Denver ranked second in yards allowed and third in points allowed defensively but were more middle of the pack offensively at 14th in points scored. Bo Nix faces some pressure of his own as his numbers dipped a bit from his rookie season to 2025 despite the Broncos having a much better record than in 2024. Denver went 4-2 over playoff teams this season. The winner of this matchup will face the winner of the Houston Texans and New England Patriots, who face off on Sunday. If the Broncos win, they will host whichever team advances, while the Bills will be on the road no matter what should they win Saturday. This game is nearly a pick ’em, as the Broncos are just 1.5-point favorites at home, per the latest DraftKings Sportsbook odds. The total is set at 46.5. The SportsLine Projection Model, which simulates every NFL game 10,000 times, leans Denver here as the Broncos win in 53% of simulations. The Bills are 9-9 against the spread this year, including the postseason, while the Broncos are 7-10 ATS. Buffalo is 9-9 to the Over this year while 10 of Denver’s 17…

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    2026-01-15 12:00:46

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