Week 10 NFL picks, score predictions, best bets today from self-learning AI

NFL Week 10 features two sets of divisional leaders in a showdown. On Sunday the AFC East leading New England Patriots led by quarterback Drake Maye face the NFC South leading Tampa Bay Buccaneers, and quarterback Baker Mayfield. Monday Night FootballJalen Hurts will lead the Philadelphia Eagles to Lambeau Field, where they will face Jordan Love’s Green Bay Packers. Both Tampa Bay (1.5 points) and Green Bay (1.5 points) enter the game as favorites. Los Angeles Rams (6-2) travel to San Francisco, where they will face the 49ers in an important NFC West game. Mac Jones, in place of Brock Purdy, will be the Niners’ starter this week as San Fran looks for a sweep of the season series following their win over L.A. during Week 5. The Rams are 5-point underdogs as Matthew Stafford tries to avenge his 26-23 overtime defeat to San Francisco in October 2. He has three wins in his last four starts versus the 49ers. Buffalo -9.5 is the largest spread left on the board. It’s against Miami. Jets vs. Browns has seen the biggest line change, as Cleveland moved from being a 2.5 point underdog to 2.5 points favorite after New York traded away Sauce Gardner and Quinnen William in separate trades just before the trade deadline. Before making any Week 10 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.New users can target the DraftKings promo code, which offers $300 in bonus bets if your bet wins + 3 months of NBA League Pass:Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions can be determined by statistically learning the historical data of each team and then quantitatively evaluating their opponent’s defensive strength by assigning a numerical value out of 100. It can be used to spot big differences in lines by constantly updating the data. SportsLine’s AI PickBot is responsible for more than 2,000 prop picks that have received a 4.5 or 5-star rating since the season began in 2023. For Week 10 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting picks for all 14 games. You can only see the AI predictions for the Week 10 NFL schedule here.New users can also target the latest Underdog promo code, good for $100 in bonus entries when you play $5 with the promo code CBSSPORTS2 in select states.Top Week 10 NFL AI picksAfter analyzing every game in Week 10, the AI says the Buffalo Bills (-9.5) cover comfortably against the struggling Miami Dolphins. Josh Allen is the leader of Buffalo’s offense. He has completed 70.4% passes for 1,833 yard and 13 touchdowns, with only four interceptions. He has also run 55 times (5.1 average), for 280 yards and seven touchdowns. Two of those came in the 28-21 victory over Kansas. City Chiefs. Buffalo’s chances have been boosted by the fact that James Cook, who has an ankle injury, is cleared to play. Miami has had a tough time of late. The Dolphins have lost their last four games including a 28-6 defeat to the Baltimore Ravens. FootballOn October 30. The Dolphins fired their long-time general manager Chris Grier after the game. SportsLine AI still rates the Bills A+ on the moneyline, and predicts an average 36-22 win despite James Cook’s ankle injury. You can bet on the Bills and see its other Week 10 predictions at SportsLine. Before you place any Week 10 NFL wagers, it is important to check out the AI’s NFL predictions. SportsLine is the only place to see them. Who will win and cover each Week 10 NFL match, and what A+ picks are you targeting? Visit SportsLine to view the top NFL picks for the week 10 games against the spread, the over-under and the money line. All from the SportsLine AI, which has made more than 2,000 high-rated predictions since the start the season in 2023.

2025-11-09 15:07:32