Week 10 of the NFL features a number of divisional rivalries. These include Bills vs. Dolphins as well as Seahawks and Cardinals. Bills have won all seven of their meetings with Miami in the past few years. This includes a 31-21 Week 3 win. This time around, the Bills are favored by 9 points on the road, according to the latest Week 10 NFL odds. SportsLine’s advanced computer model has predicted that the Bills’ top-ranked NFL offense will cover the spread and win in 55% (385.5 yards per game). The model has also predicted the Seahawks to cover at home the Cardinals’ spread by -6.5 points, and the 49ers to score Under 49.50 in their matchup with the Rams. Before locking in your Week 10 NFL picks, be sure to check out the top NFL betting picks from SportsLine’s advanced computer model. New users can also target the all-new DraftKings promo code, which offers $300 in bonus bets and three free months of NBA League Pass:The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a 47-29 streak on its top-rated picks going back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.New users can target the BetMGM bonus code, which offers up to $1,500 in bonus bets if your first bet loses:Week 10 NFL best bets for Sunday, Nov. 9 (odds subject to change): Bills (-9) vs. DolphinsSeahawks (-6.5) vs. Cardinals49ers vs. Rams: Under 49.5 points Combining the model’s three picks into a Week 10 NFL parlay would result in a payout of +602 (risk $100 to win $602). Bet it now at Caesars Sportsbook: Bills (-9) vs. DolphinsThe Bills boast the NFL’s top-ranked offense, and they’ve been spectacular on the ground, averaging 161.5 rushing yards per game, which also ranks first in the NFL. In recent weeks, the Dolphins have struggled to score points, with just six in two of their three last games. Buffalo covers the spread 55% of the time when the model predicts a Bills double-digit victory. Sam Darnold, the quarterback of the Seattle Seahawks, completed 87.5% passes for 330 yard and four touchdowns. Seattle has won eight consecutive meetings with Arizona, dominating this NFC West Rivalry. The Seahawks also have a 7-1 record against the spread over their last 8 games against Cardinals. SportsLine’s model predicts Seattle will cover the spread 56% of the time, making the Seahawks one of the top NFL picks for Week 10. Rams vs. 49ers, Under 49.5 PointsThese two NFC West opponents squared off in October 2, scoring 49 combined points to win 26-23 by overtime. Both teams struggled in the game to run the football, with the Rams finishing with fewer that 80 rushing yard. This game may also finish under the total. The total has been Under in Los Angeles’ last 12 road games against the 49ers. SportsLine’s NFL Week 10 model projects that both teams will be able to score 45 combined points on Sunday. This has helped the Under in 63% (simulations). You can now get the best picks against the spread and money lines for each Week 10 NFL matchup, based on the model’s 10,000 simulations.
2025-11-08 16:14:32
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